Abstract
A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease.
MeSH terms
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Adenosine A1 Receptor Antagonists
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Adenosine A2 Receptor Antagonists*
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Antiparkinson Agents / chemical synthesis
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Antiparkinson Agents / therapeutic use*
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Drug Design*
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Humans
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Models, Chemical
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Parkinsonian Disorders / drug therapy*
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Purines / chemical synthesis
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Purines / therapeutic use*
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Pyrazoles / chemical synthesis
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Pyrazoles / therapeutic use*
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Pyrimidines / chemical synthesis
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Pyrimidines / therapeutic use*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Adenosine A1 Receptor Antagonists
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Adenosine A2 Receptor Antagonists
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Antiparkinson Agents
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Purines
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Pyrazoles
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Pyrimidines